Axotomy mimicked by localized colchicine application.

G Pilar; L Landmesser

doi:10.1126/science.177.4054.1116

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Axotomy mimicked by localized colchicine application.

G Pilar·L Landmesser

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Abstract

Comparable depression of synaptic transmission in the avian ciliary ganglion resulted from either section or localized colchicine treatment of the ciliary nerves. Both colchicine treatment and axotomny produced similar changes in RNA distribution in the cell bodies as well. Colchicine did not directly affect transmission, and action potential propagation along the ciliary nerves was normal. Interference with axoplasmic transport of material in both cases is postulated to signal the observed chromatolytic changes.

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Action Potentials Animals Axonal Transport Axons Chickens Ciliary Body Colchicine Electric Stimulation Evoked Potentials Ganglia RNA Synaptic Transmission Journal Article

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G Pilar, L Landmesser. 1972-09-22. Axotomy mimicked by localized colchicine application.. https://doi.org/10.1126/science.177.4054.1116

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