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Adrenergic modulation of a cholinergic emotional reaction in the cat's thalamus.

L Decsi·J Nagy
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Abstract

Direct carbachol stimulation of the intralaminar nuclei of the thalamus evokes an affective defense reaction in the cat. Pretreatment of the region with noradrenaline inhibited the reaction in a dose-related manner. Phenylephrine was ineffective in this respect while isoprenaline exhibited roughly the same inhibitory action as noradrenaline. The alpha-receptor blocking dihydroergotamine left the inhibitory effect of noradrenaline unaffected while the beta-receptor blocking propranolol abolished it. These findings suggest that the inhibitory effect of noradrenaline on the carbachol-induced thalamic emotional reaction is caused by its influence on beta-type adrenergic receptors. Since a similar adrenergic-cholinergic interaction was previously demonstrated also for the hypothalamus and red nucleus, it can be concluded that adrenergic modulation of cholinergic reactions in the central nervous sytem seems to be a principle of more general validity than has been assumed thus far.

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AnimalsCarbacholCatsEmotionsFemaleMaleParasympathetic Nervous SystemSympathetic Nervous SystemThalamusJournal Article

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L Decsi, J Nagy. 1977-11-15. Adrenergic modulation of a cholinergic emotional reaction in the cat's thalamus.. https://doi.org/10.1007/bf00426580

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