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PubMed · 4144245

Osteomalacia after prolonged glutethimide administration.

R H Greenwood·F T Prunty·J Silver
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Abstract

Vitamin D deficiency is a previously unreported complication of therapy with hypnotics, and we here report a case of osteomalacia associated with long-term glutethimide administration. There was evidence of pronounced hepatic enzyme induction, and the plasma half-time of (3)H vitamin D(3) was decreased by this drug. In addition, raised levels of serum gamma-glutamyl transpeptidase, 5-nucleotidase, and leucine aminopeptidase were observed and the patient excreted large amounts of xylulose. These changes were reversed by stopping the glutethimide.

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CholecalciferolEnzyme InductionFemaleGlutethimideHalf-LifeHumansLeucyl AminopeptidaseLiverMiddle AgedNucleotidasesOsteomalaciaPentosesTritiumgamma-GlutamyltransferaseJournal Article

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R H Greenwood, F T Prunty, J Silver. 1973-03-17. Osteomalacia after prolonged glutethimide administration.. https://doi.org/10.1136/bmj.1.5854.643

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