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Histamine: effect on self-stimulation.

C K Cohn·G G Ball·J Hirsch
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Abstract

When injected discretely into the lateral hypothalamus of rats, histamine inhibited electrical self-stimulation at the injection site without affecting self-stimulation in the contralateral lateral hypothalamus. This effect was blocked by prior treatment with antihistaminics. Histidine, the amino acid precursor of histamine, produced a similar effect after a delay of 6 to 10 minutes.

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AnimalsDose-Response Relationship, DrugHistamineHistamine H1 AntagonistsHistidineHypothalamusRatsSelf StimulationStereotaxic TechniquesJournal Article

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C K Cohn, G G Ball, J Hirsch. 1973-05-18. Histamine: effect on self-stimulation.. https://doi.org/10.1126/science.180.4087.757

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