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The effect of L-ascorbate on catecholamine biosynthesis.

K J Stone·B H Townsley
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Abstract

l-Ascorbate stimulates the enzymic hydroxylation of phenylalanine in vitro by recycling tetrahydrobiopterin, which reduces O(2) utilized in the reaction. It is suggested that ascorbate might have a similar function in vivo; this would explain the apparent regulation of tyrosine hydroxylase and tryptophan hydroxylase activities by this vitamin.

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AnimalsAscorbic AcidCarbon IsotopesCatecholaminesFemaleLiverNADPOxidation-ReductionPhenylalanine HydroxylasePteridinesRatsTime FactorsTryptophan HydroxylaseTyrosineTyrosine 3-MonooxygenaseJournal Article

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K J Stone, B H Townsley. 1973. The effect of L-ascorbate on catecholamine biosynthesis.. https://doi.org/10.1042/bj1310611

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