AP2: an indispensable host factor in virus infection.

Rui Li; Yan Jiang; Xinrong Wang; Longxiang Zhang; Yue Wang

doi:10.1128/jvi.02164-25

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AP2: an indispensable host factor in virus infection.

Rui Li·Yan Jiang·Xinrong Wang·Longxiang Zhang·Yue Wang

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Abstract

Adaptor protein complex 2 (AP2), a central regulator of clathrin-mediated endocytosis and intracellular cargo trafficking, is hijacked by numerous viruses to complete their infectious cycles. This review systematically synthesizes the multifaceted roles of AP2 across the entire viral life cycle, from entry and replication to assembly and release, as well as in immune evasion. By delineating how diverse viruses exploit this key host machinery, we further consolidate the rationale and current progress in developing broad-spectrum antiviral strategies that target AP2 and its regulatory pathways. This work aims to provide a unified perspective on AP2 as a critical host-pathogen interface, offering new insights into viral pathogenesis and antiviral drug discovery.

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Humans Animals Virus Diseases Adaptor Protein Complex 2 Protein Subunits Protein Processing, Post-Translational Virus Internalization Genome, Viral Immune Evasion Antiviral Agents Host-Pathogen Interactions Virus Replication adaptor protein complex 2 antiviral drug targets immune evasion virus cellular transport virus life cycle Journal Article Review

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Rui Li, Yan Jiang, Xinrong Wang, Longxiang Zhang, Yue Wang. 2026-01-21. AP2: an indispensable host factor in virus infection.. https://doi.org/10.1128/jvi.02164-25

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