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Proteomic pathways mediating low socioeconomic status and cardiovascular events in older adults in CHS and ARIC.

Michelle C Odden·Xiaojuan Liu·Amil M Shah·Yimin Yang·Victoria Lamberson·Jennifer A Brody·Colleen M Sitlani·Matt Huber·Rizwan Kalani·Ali Shojaie·Laura M Raffield·LáShauntá Glover·Priya Palta·Anna M Kucharska-Newton·Bruce M Psaty·James S Floyd
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Abstract

BACKGROUND AND AIMS: Many studies have linked socioeconomic status (SES) and cardiovascular outcomes, yet the biologic mechanisms mediating these associations are only partially understood. The objective of this study was to identify molecular mediators of the association of low SES with coronary heart disease (CHD) and stroke. METHODS: This research was conducted in 2942 Black and White adults in the Cardiovascular Health Study (mean age 76.2 years) and 10,689 Black and White adults in the Atherosclerosis Risk in Communities Study (mean age 60.0 years). We used factor analysis to create a composite measure of low educational attainment, low-income, and blue-collar occupation. Approximately 5000 proteins were measured with an aptamer-based method, and CHD and stroke events were adjudicated. Results were stratified by race, which was conceptualized as a social factor. RESULTS: Low SES was associated with 44 and 262 proteins, in Black and White adults, respectively. No protein met the Bonferroni adjusted threshold for statistically significantly mediation among Black participants. Among White participants, 23 proteins mediated the association between SES adversity and CHD and 5 mediated the association between SES adversity and stroke. The strongest mediating associations for CHD included PTPRS, SCG3, and MMP12. The strongest mediating associations for stroke included NCAN, FAM20B, and APLP1. SPARCL1 and CDCP1 remained the strongest mediators of the association between SES adversity and CHD, after adjusting for potential confounders and traditional cardiovascular risk factors. CONCLUSION: We identified several biomarkers that characterize the biologic risk of SES adversity on CHD and stroke.

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AgedFemaleHumansMaleMiddle AgedBiomarkersBlack or African AmericanCoronary DiseaseHeart Disease Risk FactorsLow Socioeconomic StatusProspective StudiesProteomicsRisk AssessmentRisk FactorsSocial ClassSocioeconomic Disparities in HealthStrokeUnited StatesWhiteBiologic pathwaysCoronary heart diseaseMendelian randomizationSocioeconomic adversityJournal ArticleMulticenter Study

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Michelle C Odden, Xiaojuan Liu, Amil M Shah, Yimin Yang, Victoria Lamberson, Jennifer A Brody, Colleen M Sitlani, Matt Huber, Rizwan Kalani, Ali Shojaie, Laura M Raffield, LáShauntá Glover, Priya Palta, Anna M Kucharska-Newton, Bruce M Psaty, James S Floyd. 2026-03-13. Proteomic pathways mediating low socioeconomic status and cardiovascular events in older adults in CHS and ARIC.. https://doi.org/10.1016/j.atherosclerosis.2026.120705

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