PubMed · 4186300
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J M Little, J P Halliday, D C Gleen. 1969-10-18. Pseudomyxoma peritonei.. https://pubmed.ncbi.nlm.nih.gov/4186300/
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p53 gene mutations are among the most common genetic lesions in human cancers. While previous studies have established the presence of p53 protein in ovarian carcinomas some have not shown the alteration of the p53 gene to be a feature in benign or borderline ovarian epithelial neoplasms. In this study we examined both benign and borderline malignant/malignant mucinous neoplasms for p53 protein accumulation by the means of an anti-human p53 protein monoclonal antibody on paraffin sections. Our results show that p53 protein accumulation is associated to a similar degree with both malignant mucinous cystadenocarcinomas and mucinous cystademonas of borderline malignancy. This suggests that p53 mutations may play an important and early role in the malignant transformations of one-third or more of mucinous ovarian neoplasms. Furthermore, among the mucinous cystadenomas of borderline malignancy where p53 staining was present, staining could be found in the morphologically benign areas thus indicating that, despite their innocuous appearance, such epithelial cells might have already taken a very important step in their evolution to frank malignancy.
We describe the clinical and pathologic findings of a patient with mixed blastoma-germ cell malignancy primary in the lung. Serum alpha-fetoprotein levels were elevated at presentation, and normalized with anti-germ cell chemotherapy. The resection specimen contained massively necrotic germ cell tumor with viable mature neural tissue, plus viable biphasic blastoma with stromal bone and skeletal muscle differentiation. It is not clear whether the germ cell component represents unusual differentiation of a somatic cell line or whether the blastoma component represents an unusual pattern of teratomatous differentiation.
We report a case of prostatic cystadenoma in a 45-year-old man with the complaint of urinary retention. The large mass was palpated on rectal examination. The tumor was localized in the position of the left lobe of the prostate and was seen as multi-ocular on computerized tomographic (CT) scan. The serum levels of prostatic acid phosphatase (PAP) and prostate specific antigen (PSA) were slightly elevated. The tumor was enucleated retropubically, it weighed 210 g and had an multilocular structure macroscopically. The cyst seen on microscopic examination was lined with cuboidal or columnar epithelial cells and the lining cells were focally multilayered and formed papillary projections. The stroma surrounding the glands was composed of fibrous tissue containing smooth muscle fibers. The epithelial cells were immunoreactive for PAP and PSA.