Understanding Candidozyma (Candida) auris: genomic evolution, antifungal resistance and the growing challenges in global infection control.

Karoline Kristina Kemmerich; Su&#xe9;len Andreia Rossi; Jo&#xe3;o N&#xf3;brega de Almeida J&#xfa;nior; Arnaldo Lopes Colombo; Lysangela Ronalte Alves

doi:10.1099/jmm.0.002135

PubMed · 41875028

Understanding Candidozyma (Candida) auris: genomic evolution, antifungal resistance and the growing challenges in global infection control.

Karoline Kristina Kemmerich·Suélen Andreia Rossi·João Nóbrega de Almeida Júnior·Arnaldo Lopes Colombo·Lysangela Ronalte Alves

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Abstract

Candida auris (recently renamed Candidozyma auris) is an emerging multidrug-resistant fungal pathogen, first identified in Japan in 2009. C. auris exhibits remarkable persistence on human skin and inanimate surfaces, resistance to multiple antifungals, notably fluconazole, and biofilm formation, which hinders infection control and leads to hospital outbreaks with high mortality rates. Despite ongoing research, key aspects of its reservoir origin, transmission routes and the best way to combat its spread and multidrug resistance remain unclear. Improving genomic surveillance and antifungal strategies is crucial to contain its spread and mitigate the growing public health threat posed by this resilient and potentially fatal fungal pathogen.

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Humans Antifungal Agents Candida auris Cross Infection Drug Resistance, Fungal Infection Control Drug Resistance, Multiple, Fungal Biofilms Candidiasis Evolution, Molecular Genome, Fungal biofilm formation environmental persistence hospital-acquired infections multidrug-resistant fungi nosocomial outbreaks virulence factors Journal Article Review

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Karoline Kristina Kemmerich, Suélen Andreia Rossi, João Nóbrega de Almeida Júnior, Arnaldo Lopes Colombo, Lysangela Ronalte Alves. 2026. Understanding Candidozyma (Candida) auris: genomic evolution, antifungal resistance and the growing challenges in global infection control.. https://doi.org/10.1099/jmm.0.002135

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