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Non-Cancer Causes of Death in Patients With Metastatic Hormone-Sensitive Prostate Cancer: A Real-World Analysis.

Marta Garcia de Herreros·Clara Rodrigo·Laura Ferrer-Mileo·Laia Fernández-Mañas·Joel Mases·Nely Diaz·Antoni Vilaseca·Mariana Altamirano·Roser Gibanel·Maria José Ribal·Natalia Jimenez·Oscar Reig·Mariona Figols·Miguel Ángel Climent·Albert Font·Begoña Mellado
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Abstract

BACKGROUND: As overall survival improves in metastatic hormone-sensitive prostate cancer (mHSPC), non-cancer causes of death are increasingly relevant. METHODS: We conducted a real-world multicenter study of patients diagnosed with mHSPC treated with ADT alone or in combination. Causes of death before progression to castration-resistant prostate cancer (CRPC) were classified as cancer- or non-cancer-related. Deaths were classified as non-cancer-related if they occurred in the absence of cancer progression. RESULTS: Among 565 patients, 35 (6.2%) died from non-cancer-related causes without disease progression, mainly infections (34%) and cardiovascular events (20%). CONCLUSIONS: Non-cancer mortality represents a meaningful proportion of deaths in mHSPC, supporting systematic cardiovascular risk evaluation and infection-prevention strategies.

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HumansMaleProstatic NeoplasmsCause of DeathAgedAndrogen AntagonistsAged, 80 and overCardiovascular DiseasesNeoplasm MetastasisMiddle AgedProstatic Neoplasms, Castration-ResistantDisease Progressioncardiovascular riskcomorbiditiesnon‐cancer mortalityprostate cancerJournal ArticleMulticenter Study

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Marta Garcia de Herreros, Clara Rodrigo, Laura Ferrer-Mileo, Laia Fernández-Mañas, Joel Mases, Nely Diaz, Antoni Vilaseca, Mariana Altamirano, Roser Gibanel, Maria José Ribal, Natalia Jimenez, Oscar Reig, Mariona Figols, Miguel Ángel Climent, Albert Font, Begoña Mellado. 2026-05-03. Non-Cancer Causes of Death in Patients With Metastatic Hormone-Sensitive Prostate Cancer: A Real-World Analysis.. https://doi.org/10.1002/pros.70174

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