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Oro-esophageal feeding for tracheostomized patients with severe traumatic brain injury: a randomized controlled trial.

Dandan Lv·Hongyan Liu·Jing Zhao·Yang Liu·Qianqian Li·Xing'na Zhao·Liugen Wang·Xi Zeng·Yu Ding
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Abstract

BACKGROUND: This study reports the clinical effects of intermittent oro-esophageal tube feeding (IOE) versus nasogastric tube feeding (NGT) on nutritional status, aspiration pneumonia, decannulation, and level of consciousness in tracheostomized patients with severe traumatic brain injury (sTBI). METHODS: A randomized controlled trial was conducted between March 2024 and October 2025 in China and included tracheostomized patients with sTBI. Participants were randomized 1:1 to the intervention and control groups for 28-day interventions. IOE or NGT was used for nutritional supports, respectively. The primary outcome was nutritional status, including hemoglobin, albumin, prealbumin and body mass index. The secondary outcomes included aspiration pneumonia, decannulation, and level of consciousness assessed using the Glasgow Coma Scale (GCS). Generalized linear mixed-effects models, generalized estimating equations, and Cox regression were used for data analyze. RESULTS: A total of 104 participants were included in the analysis. After intervention, significant interaction effects were observed in hemoglobin (&#x3b2;&#x2009;=&#x2009;5.272, 95% CI: 2.707, 7.837), albumin (&#x3b2;&#x2009;=&#x2009;3.675, 95% CI: 1.854, 5.496), prealbumin (&#x3b2;&#x2009;=&#x2009;11.835, 95% CI: 6.623, 17.047), body mass index (&#x3b2;&#x2009;=&#x2009;1.719, 95% CI: 0.868, 2.569), the GCS (&#x3b2;&#x2009;=&#x2009;0.981, 95% CI: 0.572, 1.390), and aspiration pneumonia (OR= 0.304, 95% CI: 0.133, 0.693). The Cox model revealed that group significantly influenced the decannulation outcomes [HR (95% CI) =5.556 (3.197, 9.657), p&#x2009;<&#x2009;0.001]. CONCLUSIONS: In tracheostomized patients with sTBI who received routine treatment, IOE is more conducive to decannulation and the improvement in nutritional status, aspiration pneumonia, and level of consciousness than NGT. CLINICAL TRIAL REGISTRATION: Prospectively registered at ClinicalTrials.gov (NCT06328985, 03/18/2024, clinicaltrials.gov/study/NCT06328985).

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HumansMaleBrain Injuries, TraumaticFemaleEnteral NutritionAdultPneumonia, AspirationNutritional StatusTracheostomy DecannulationTracheostomyIntubation, GastrointestinalChinaMiddle AgedTreatment OutcomeGlasgow Coma ScaleNGTTraumatic brain injurydysphagiaintermittent oro-esophageal tube feedingnasogastric tuberehabilitationtracheostomyJournal ArticleRandomized Controlled TrialResearch Support, Non-U.S. Gov't

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Dandan Lv, Hongyan Liu, Jing Zhao, Yang Liu, Qianqian Li, Xing'na Zhao, Liugen Wang, Xi Zeng, Yu Ding. 2026-06-09. Oro-esophageal feeding for tracheostomized patients with severe traumatic brain injury: a randomized controlled trial.. https://doi.org/10.1080/07853890.2026.2685913

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