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Epigenomic profiling links IGF2 overexpression to anthracycline resistance in colorectal cancer organoids.

Tara L Hogenson·William J Phillips·Merih D Toruner·Zachry S Poshusta·Luciana L Almada·Hao Xie·Ryan M Carr·Jenny J Li·David L Marks·Renzo E Vera·Erik Jessen·Michael T Barrett·Joleen M Hubbard·Travis E Grotz·Martin E Fernandez-Zapico
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Abstract

This study provides evidence of a new treatment approach for colorectal peritoneal metastases, a condition associated with a worse prognosis than other types of metastases.

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HumansColorectal NeoplasmsDrug Resistance, NeoplasmInsulin-Like Growth Factor IIOrganoidsEpigenomicsAnthracyclinesGene Expression Regulation, NeoplasticAnimalsPeritoneal NeoplasmsGastroenterologyOncologyTherapeuticsJournal ArticleResearch Support, N.I.H., Extramural

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Tara L Hogenson, William J Phillips, Merih D Toruner, Zachry S Poshusta, Luciana L Almada, Hao Xie, Ryan M Carr, Jenny J Li, David L Marks, Renzo E Vera, Erik Jessen, Michael T Barrett, Joleen M Hubbard, Travis E Grotz, Martin E Fernandez-Zapico. 2026-07-16. Epigenomic profiling links IGF2 overexpression to anthracycline resistance in colorectal cancer organoids.. https://doi.org/10.1172/jci.insight.195194

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