Generation of induced pluripotent stem cell line NTUHi003-A from a patient with premature ovarian insufficiency.

Yu-An Chen; Chen-Yu Lu; Chia-En Wu; Tzu-Hsin Chen; Huai-En Lu; Hsin-Fu Chen; Chu-Chun Huang

doi:10.1016/j.scr.2026.104076

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Generation of induced pluripotent stem cell line NTUHi003-A from a patient with premature ovarian insufficiency.

Yu-An Chen·Chen-Yu Lu·Chia-En Wu·Tzu-Hsin Chen·Huai-En Lu·Hsin-Fu Chen·Chu-Chun Huang

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Abstract

Premature ovarian insufficiency (POI) is characterized by impaired ovarian function before 40 years of age and is associated with heterogeneous etiologies. Herein, we established a human induced pluripotent stem cell (hiPSC) line, NTUHi003-A, from the peripheral blood mononuclear cells (PBMCs) of a patient with POI. The generated hiPSC line exhibited a normal 46, XX karyotype and demonstrated confirmed pluripotency. This cell line provides a valuable cellular platform for disease modeling and mechanistic studies of POI.

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Humans Female Induced Pluripotent Stem Cells Primary Ovarian Insufficiency Cell Line Adult Cellular Reprogramming Leukocytes, Mononuclear Cell Differentiation Disease modeling Induced pluripotent stem cells Premature ovarian insufficiency Sendai virus reprogramming Journal Article

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Yu-An Chen, Chen-Yu Lu, Chia-En Wu, Tzu-Hsin Chen, Huai-En Lu, Hsin-Fu Chen, Chu-Chun Huang. 2026-08-11. Generation of induced pluripotent stem cell line NTUHi003-A from a patient with premature ovarian insufficiency.. https://doi.org/10.1016/j.scr.2026.104076

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