PubMed · 4267462
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1972-12-09. [Immunologic lung diseases].. https://pubmed.ncbi.nlm.nih.gov/4267462/
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We present the case of a 50-year-old man who underwent kidney biopsy for nephrotic syndrome. In addition to a membranous pattern, anti-glomerular basement membrane (anti-GBM) staining was noted before manifestations of anti-GBM disease. Hematuria and renal failure ensued 2 weeks later. In addition, he had simultaneous circulating levels of anti-GBM antibody and both perinuclear (P-) and cytoplasmic (C-) antineutrophil cytoplasmic antibody (ANCA).
Immune complex glomerulonephritis can be superimposed on diabetic glomerulosclerosis. Idiopathic membranous glomerulonephritis, immunoglobulin (Ig) A glomerulonephritis, Henoch-Schönlein nephritis, membranoproliferative glomerulonephritis, minimal change glomerulonephritis, postinfectious glomerulonephritis, lupus nephritis, amyloidosis, focal segmental glomerulosclerosis, and rarely crescentic glomerulonephritis can all occur with diabetic nephropathy. We describe for the first time an unusual case of diabetic nephropathy coexistent with anti-glomerular basement membrane (GBM) nephritis. The renal function of this patient improved with plasmapheresis and immunosuppressives. We also review the literature on coexistent rapidly progressive glomerulonephritis (RPGN) and diabetic nephropathy.