Regional ventricular enlargement as an in vivo biomarker of cumulative biomechanical neurodegeneration in former American football players.

Brian Szekely; Jared Stearns; Anya S Mirmajlesi; Rebecca D Folkerth; Sylvain Bouix; Daniel H Daneshvar; Charles H Adler; Charles Bernick; Laura J Balcer; Jeffrey L Cummings; Eric M Reiman; Robert A Stern; Martha E Shenton; Richard J Rushmore; Hector Arciniega; DIAGNOSE CTE Research Project

doi:10.1002/alz.71764

PubMed · 42675309

Regional ventricular enlargement as an in vivo biomarker of cumulative biomechanical neurodegeneration in former American football players.

Brian Szekely·Jared Stearns·Anya S Mirmajlesi·Rebecca D Folkerth·Sylvain Bouix·Daniel H Daneshvar·Charles H Adler·Charles Bernick·Laura J Balcer·Jeffrey L Cummings·Eric M Reiman·Robert A Stern·Martha E Shenton·Richard J Rushmore·Hector Arciniega·DIAGNOSE CTE Research Project

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Abstract

INTRODUCTION: Repetitive head impacts (RHIs) have been linked to later life neurodegeneration, yet the in vivo structural correlates of cumulative biomechanical loading remain unclear. We examined whether regional ventricular morphology in former American football players reflects exposure burden and traumatic encephalopathy syndrome (TES) classification. METHODS: Participants included 170 male former football players and 54 age-matched asymptomatic male controls from the Diagnostics, Imaging, and Genetics Network for the Objective Study and Evaluation of Chronic Traumatic Encephalopathy Research Project. Subject-specific manual segmentation quantified lateral ventricle, inferior horn, third ventricle, and fourth ventricle volumes. Group and exposure associations were tested using generalized least squares models. RESULTS: Former players showed larger left inferior lateral ventricle volume than controls, with the largest effects among professional players. Greater cumulative linear and rotational acceleration exposure was associated with enlargement across lateral ventricular and inferior horn regions. DISCUSSION: Regional ventricular enlargement may represent an in vivo marker of cumulative biomechanical loading after RHI exposure.

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Humans Male Football Magnetic Resonance Imaging Biomechanical Phenomena Biomarkers Cerebral Ventricles United States Chronic Traumatic Encephalopathy American football chronic traumatic encephalopathy cumulative head impact index neuroimaging repetitive head impacts structural magnetic resonance imaging traumatic encephalopathy syndrome ventricular volume Journal Article

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Brian Szekely, Jared Stearns, Anya S Mirmajlesi, Rebecca D Folkerth, Sylvain Bouix, Daniel H Daneshvar, Charles H Adler, Charles Bernick, Laura J Balcer, Jeffrey L Cummings, Eric M Reiman, Robert A Stern, Martha E Shenton, Richard J Rushmore, Hector Arciniega, DIAGNOSE CTE Research Project. 2026. Regional ventricular enlargement as an in vivo biomarker of cumulative biomechanical neurodegeneration in former American football players.. https://doi.org/10.1002/alz.71764

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