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Autologous bone grafts versus alloplastic implants for orbital floor reconstruction: a systematic review and meta-analysis.

Mohammed Ehmidat·Ahmed Samy Gad·Ahmad Omar Saleh·Mohamed Mahmoud Fathy·Abdelrahman A Ebaid·Amir Majdi Moh'd·Raneem Abuqtaish·Mahmoud Abdelbaki·Amr Elzahy·Omar Osman
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Abstract

PURPOSE: The choice of reconstructive material for orbital floor fractures remains a subject of debate. While autologous bone has historically been considered the "gold standard," alloplastic implants offer potential advantages in reducing surgical morbidity. This meta-analysis aimed to compare the safety and efficacy of autologous bone grafts versus alloplastic implants in orbital floor reconstruction. METHODS: A systematic review was conducted in accordance with PRISMA guidelines (PROSPERO: CRD420251140583). Electronic databases (PubMed, Scopus, Web of Science, Cochrane Library) were searched from inception to August 2025. Randomized controlled trials and comparative cohort studies evaluating functional outcomes (diplopia, enophthalmos) and complications (ectropion, infection, malposition) were included. Data were synthesized using a random-effects model, with risk ratios (RR) and 95% confidence intervals (CI) calculated. RESULTS: Twenty studies comprising 2,119 patients were included. Alloplastic implants demonstrated statistically significant superiority in periocular safety, with a reduced risk of postoperative ectropion compared to autologous grafts (RR = 2.245; p = 0.020). In an exploratory sensitivity analysis excluding one outlier study, autologous grafts were associated with a significantly higher risk of implant malposition (RR = 2.074; p = 0.004). Autologous reconstruction was associated with a strong trend toward increased postoperative pain (p = 0.052) and inherent donor-site morbidity. No statistically significant differences were observed regarding infection (p = 0.402), enophthalmos (p = 0.201), or diplopia (p = 0.221). CONCLUSION: Alloplastic implants were associated with a lower risk of ectropion and implant malposition, with functional outcomes statistically comparable to autologous bone. Given the elimination of donor-site morbidity, alloplastic biomaterials represent a safe and effective alternative for orbital floor reconstruction; however, the predominance of retrospective, heterogeneous studies in the current evidence base means these findings should inform, rather than replace, individualized surgical decision-making pending further high-quality randomized trials.

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HumansOrbital FracturesPlastic Surgery ProceduresBone TransplantationOrbital ImplantsPostoperative ComplicationsTransplantation, AutologousBone SubstitutesOrbitAutograftsAlloplastic implantsAutologous boneEctropionMeta-analysisOrbital fracturesOrbital reconstructionJournal ArticleSystematic ReviewMeta-AnalysisComparative Study

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Mohammed Ehmidat, Ahmed Samy Gad, Ahmad Omar Saleh, Mohamed Mahmoud Fathy, Abdelrahman A Ebaid, Amir Majdi Moh'd, Raneem Abuqtaish, Mahmoud Abdelbaki, Amr Elzahy, Omar Osman. 2026-09-03. Autologous bone grafts versus alloplastic implants for orbital floor reconstruction: a systematic review and meta-analysis.. https://doi.org/10.1007/s10006-026-01634-5

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