Studies on the coupling rates in liquid-phase peptide synthesis using competition experiments.

M Mutter

doi:10.1111/j.1399-3011.1979.tb01879.x

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Studies on the coupling rates in liquid-phase peptide synthesis using competition experiments.

M Mutter

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Abstract

Competition experiments were carried out in order to determine relative reaction rates, Vrel, for the peptide-forming step. Using the liquid-phase method of peptide synthesis a model system was developed to investigate the influence of coupling method, amino component, derivatization and solvent upon Vrel. According to a standard procedure, Vrel for all 20 commonly occurring amino acids were established. A strong dependence of Vrel upon steric effects of the coupling components was found. The data obtained may serve as a guideline for optimizing the reaction conditions in peptide synthesis.

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M Mutter. 1979. Studies on the coupling rates in liquid-phase peptide synthesis using competition experiments.. https://doi.org/10.1111/j.1399-3011.1979.tb01879.x

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