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Peripheral catecholamines and memory: characteristics of syrosingopine-induced amnesia.

T J Walsh·T Palfai
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Abstract

The effect of syrosingopine on retention of a passive avoidance trial in mice was investigated. The drug given in doses of 2.5, 4.0 or 6.0 mg/kg 2 hr before training, but not when given 24 or 0.5 hr or immediately after training, resulted in amnesia 7 days later. Dopamine or norepinephrine administered systemically 15 min before to 10 min after training was able to block the syrosingopine-induced amnesia. The role of peripheral catecholamines in memory formation was discussed.

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AmnesiaAnimalsAvoidance LearningCatecholaminesDopamineDrug InteractionsHumansMaleMemoryMiceNorepinephrineReserpineTime FactorsJournal Article

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T J Walsh, T Palfai. 1979. Peripheral catecholamines and memory: characteristics of syrosingopine-induced amnesia.. https://doi.org/10.1016/0091-3057(79)90123-0

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