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Nitrosomethylurea (MNU): a powerful carcinogen for mouse skin. A study utilising the tetrazolium test (TZT) and topical skin applications.

O H Iversen
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Abstract

Nitrosomethylurea (MNU) was tested with the tetrazolium test for skin carcinogens with positive results. 39 hairless mice were painted once a week with a 1% solution of MNU in acetone. After 18 weeks all the animals bore tumours and 90% had skin carcinomas. Hence, the strong carcinogenic potency of MNU was confirmed, and the validity of the tetrazolium test was given further support.

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AnimalsCarcinogensMethylnitrosoureaMiceMice, NudeNitrosourea CompoundsSkin NeoplasmsTetrazolium SaltsJournal Article

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O H Iversen. 1979-06-29. Nitrosomethylurea (MNU): a powerful carcinogen for mouse skin. A study utilising the tetrazolium test (TZT) and topical skin applications.. https://doi.org/10.1007/bf02889114

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