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Improved method for morphine extraction from biological samples.

G L Sprague·A E Takemori
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Abstract

Methadone morphine, or naloxone extraction from brain homogenates, plasma, and urine is described. An aqueous sample was loaded on a surgical gauze support, which was washed with extracting solvents. Aqueous samples remained on the support, and nonpolar drugs partitioned into the lipophilic extracting solvent. The procedure recovered 80-100% of nanogram levels of methadone, morphine, or naloxone from biological samples. In addition, an approximate 10-fold timesaving capacity was demonstrated compared to standard liquid-liquid extraction techniques.

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AnimalsBrain ChemistryChromatography, Thin LayerMaleMethadoneMethodsMiceMorphineNaloxoneJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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BibTeXRIS

G L Sprague, A E Takemori. 1979. Improved method for morphine extraction from biological samples.. https://doi.org/10.1002/jps.2600680543

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