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PubMed · 43117

An investigation into the roles of synaptic vesicular Mg++-ATPase in neurotransmitter release, using benzhydryl piperazines.

M G Wyllie·J C Gilbert
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Abstract

A series of benzhydryl piperazines was found to inhibit synaptic vesicular Mg++-ATPase. These compounds were also found to increase basal and evoked release of noradrenaline from synaptosomes. A comparison was made between the concentrations effective in inhibiting the enzyme and promoting noradrenaline release. In general, as the degree of Mg++-ATPase inhibition increased, noradrenaline release was increased. The relevance of these findings to a possible role of Mg++-ATPase in noradrenaline release is discussed.

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AcetylcholineAdenosine TriphosphatasesAnimalsBenzhydryl CompoundsIn Vitro TechniquesMagnesiumMaleNeurotransmitter AgentsNorepinephrinePiperazinesRatsSynaptic VesiclesJournal Article

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M G Wyllie, J C Gilbert. 1979. An investigation into the roles of synaptic vesicular Mg++-ATPase in neurotransmitter release, using benzhydryl piperazines.. https://pubmed.ncbi.nlm.nih.gov/43117/

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