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Dimethylformamide and alcohol intolerance.

W H Lyle·T W Spence·W M McKinneley·K Duckers
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Abstract

Facial flushing and other symptoms were reported by 19 of a group of 102 men who worked with dimethylformamide (DMF). Twenty-six of the 34 episodes occurred after the workers had consumed alcoholic drinks. The metabolite N-methylformamide (MF) was detected in the urine on 45 occasions, the highest recorded concentration being 77 microliter/litre. The highest recorded concentration of DMF in air was 200 ppm. The DMF-ethanol reaction is possibly attributable to the inhibition of acetaldehyde metabolism, probably by MF.

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Air Pollutants, OccupationalDimethylformamideDrug InteractionsEthanolFaceFormamidesHumansMaleTime FactorsVasodilationJournal Article

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W H Lyle, T W Spence, W M McKinneley, K Duckers. 1979. Dimethylformamide and alcohol intolerance.. https://doi.org/10.1136/oem.36.1.63

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