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Leonurine, an improved synthesis.

K F Cheng·C S Yip·H W Yeung·Y C Kong
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Abstract

Leonurine (1) is the uterotonic principle of Leonurus artemisia. We have developed a simple, high-yield synthetic procedure of 1 that is adaptable to large scale preparation. The synthesis involves the condensation of syringic acid and 4-guanidino-1-butanol hydrochloride in the presence of DDC using 1:1 HMPT-ether as solvent. The synthetic leonurine showed uterotonic activity in vivo and in vitro.

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AnimalsFemaleGallic AcidGuanidinesHumansIn Vitro TechniquesMethodsRatsUterine ContractionBiologyDelivery Of Health CareGenitaliaGenitalia, FemaleHealthHealth ServicesMedicinePhysiologyPlants, MedicinalUrogenital SystemUterusJournal Article

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K F Cheng, C S Yip, H W Yeung, Y C Kong. 1979-05-15. Leonurine, an improved synthesis.. https://doi.org/10.1007/bf01960323

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