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PubMed · 4470915

Electron microscopic studies in hereditary nephritis.

J Churg·L Strauss·R L Sherman
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Abstract

A characteristic electron microscopic lesion-longitudinal splitting of the glomerular basement membranes with accumulation of dark particles-was found in some cases of hereditary nephritis, especially in Alport syndrome. A somewhat similar but less specific alteration was present in the tubular basement membranes and in the Bowman capsule. The lesions tended to exhibit a familial segregation. The possible pathogenesis of the lesions and their relation to physiologic abnormalities are briefly discussed.

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Basement MembraneHumansKidney GlomerulusKidney TubulesMicroscopy, ElectronNephritisJournal Article

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J Churg, L Strauss, R L Sherman. 1974. Electron microscopic studies in hereditary nephritis.. https://pubmed.ncbi.nlm.nih.gov/4470915/

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