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PubMed · 44710

Separation of drugs by high-performance liquid chromatography with porous polymer resins.

R Matsuda·T Yamamiya·M Tatsuzawa·A Ejima·N Takai
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Abstract

The separation of cold drugs and neuroleptics by high-performance liquid chromatogarphy with the porous polymer resin DVB-MCL-O (or 11-30-0), which is a styrene-divinylbenzene-methyl methacrylate copolymer substituted with hydroxymethyl groups, was studied. This copolymer was compared with the commercial porous polymers Hitachi gel 3011, 3011-0 and 3030. A very small theoretical plate height was obtained by using DVB-MCL-O and methanol-ammonia solution (99:1) as the stationary and mobile phases, respectively. This combination was found to be the most suitable for the rapid separation of condensed aromatic ring compounds.

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AnalgesicsAntipsychotic AgentsChromatography, High Pressure LiquidHydrogen-Ion ConcentrationPharmaceutical PreparationsPolymersResins, SyntheticJournal Article

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R Matsuda, T Yamamiya, M Tatsuzawa, A Ejima, N Takai. 1979-05-11. Separation of drugs by high-performance liquid chromatography with porous polymer resins.. https://doi.org/10.1016/s0021-9673(01)80447-7

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