PubMed · 449001
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J B Henry, R C Hubbell. 1979-08-17. Blood resource management.. https://pubmed.ncbi.nlm.nih.gov/449001/
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The large-scale use of frozen red cells and washed red cells in this transfusion service has not been effective in reducing post-transfusion hepatitis. Seventy-eight per cent of 31,125 transfusions, excluding platelets and plasma, were given in the form of frozen or washed red cells. These transfusions were associated with 56 cases of hepatitis. In 37 cases, the recipients had received only frozen or washed red cells (or both). Post-transfusion hepatitis was of the non-A, non-B type in 95% of cases. On average, commercial blood accounted for 30 per cent of the donor base during the first four years and was involved in 44 of the 56 cases. Elimination of commercial blood from the donor base resulted in a decrease in the incidence of hepatitis from 2.1 to 0.3 per 1000 transfusions.
Review of the clinical records of 103 patients participating in a community-blood-bank-sponsored autologous transfusion program confirmed the safety of autologous blood and the practically of such a community-centered program. There were no transfusion reactions, increased morbidity, or reports of hepatitis among the autologous donor-patients. A previously unobserved phenomenon was that surgeons tended to transfuse less blood to patients who had autologous blood available, rarely exceeding the number donated, although this varied from one to three units for similar surgery. Only eight of the 103 patients intentionally received a transfusion with homologous blood in addition to their autologously donated blood. Patients, their physicians, and the blood bank can all benefit substantially from such a program.
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