Iproniazid-induced biochemical changes in mice.

R P Maickel; D R Bowman; N Fedynskyj; W R Snodgrass; M P Ryan

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PubMed · 451348

Iproniazid-induced biochemical changes in mice.

R P Maickel·D R Bowman·N Fedynskyj·W R Snodgrass·M P Ryan

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Abstract

Single doses of iproniazid to Swiss-Webster mice caused a prolonged hypoglycemic reaction and transient biphasic changes in liver triglycerides. In contrast, the same dose of iproniazid in mice on a pyridoxine deficient diet elevated plasma glucose and FFA and liver FFA and TGL. Administration of the same dose of ipioniazid for 30 days elevated liver TGL in Swiss-Webster, C57/B1, DBA, and AKR mice; this effect was reversed in all but the AKR mice when the animals were maintained on a pyrodoxine-deficient diet.

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Animals Blood Glucose Fatty Acids, Nonesterified Iproniazid Lipid Metabolism Liver Male Mice Mice, Inbred Strains Time Factors Triglycerides Vitamin B 6 Deficiency Journal Article Research Support, U.S. Gov't, P.H.S.

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R P Maickel, D R Bowman, N Fedynskyj, W R Snodgrass, M P Ryan. 1979. Iproniazid-induced biochemical changes in mice.. https://pubmed.ncbi.nlm.nih.gov/451348/

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