PubMed · 4543773
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A Brzecki, E Gulewicz. [Oscillopsia].. https://pubmed.ncbi.nlm.nih.gov/4543773/
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PURPOSE: To report a unique case of a woman who developed simultaneous bilateral maculopathy presumed to result from intake of sertraline hydrochloride, a serotonin reuptake inhibitor. METHODS: Full clinical ocular examination, color vision testing, automated static perimetry, electroretinography, electrooculography and fundus fluorescein angiography were performed. Living members of her family were also examined. RESULTS: The patient had normal electroretinography and electrooculography results. Automated static perimetry showed generalized reduction of sensitivity and central scotomas. Macular lesions resolved 6 months after discontinuation of sertraline, however, during twenty months of follow-up her visual acuity and abnormalities in other psychophysical tests did not improve. CONCLUSION: Patients started on sertraline should be informed of the potential risk of developing maculopathy, and they should be examined regularly to detect possible early alterations.
The development of visual and vestibular control of smooth gaze adjustments was studied longitudinally in 3- to 18-week-old infants. Eye and head movements were measured with electro-oculography (EOG) and an optoelectronic system, respectively. The infant was placed in a chair providing full support to the trunk but allowing relatively free head movements. The chair was positioned at the center of a striped-patterned drum. The chair and the drum were oscillated sinusoidally, either individually or in synchrony at 0.25 Hz. When the drum oscillated around the infant (the optokinetic response condition, OKR), the gain of both smooth eye and head tracking components was low up to 6 weeks of age, after which the eye gain increased dramatically and the lag decreased. The most substantial increase in head gain was observed at 13-18 weeks of age. When only the chair was oscillated (visual VOR, VVOR), the compensatory eye gain was high at 3 weeks and the head contributed significantly to the compensation (vestibulocollic reflex, VCR). The head gain increased significantly at 13-18 weeks of age as in the OKR case. When the drum and the chair were oscillated synchronously (inhibition of VOR, VORINHIB), the compensatory eye gain was significantly lower than in the VVOR, indicating suppression of VOR. This effect was considerable at 3 weeks. However, VCR was not suppressed but comparable to the VVOR condition at all ages studied. In summary, we found that the vestibular control of smooth gaze adjustment functions earlier than the visual control. At 2 months, the visual control improves dramatically and at 3-4 months head participation increases considerably. The eye gain in the VORINHIB condition could be well predicted by vector addition of the eye position signals in the OKR and VVOR conditions.
BACKGROUND: It has long been a goal to develop a means to measure squint angles in three dimensions simultaneously. A three-dimensional binocular method is naturally needed especially with surgical procedures that affect three dimensions of ocular motility. METHODS: Special modifications of a videographic method provide simultaneous online data on the three-dimensional position of the eyes. The interocular difference is equal to the amount of squint, depending on the direction of gaze, head-tilt/direction of gravity, and convergence. RESULTS: The method introduced provides three-dimensional and binocular documentation of ocular movements. This could lead to improved pre- and postsurgical examination, especially of rotational disturbances, and it could also offer an objective means for comparing the results of various surgical procedures.