PubMed · 4551771
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T Nomura. 1972. [Hematology].. https://pubmed.ncbi.nlm.nih.gov/4551771/
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OBJECTIVE: To determine the effect of stanozolol on body composition, nitrogen balance, and food consumption in castrated dogs with chronic renal failure. DESIGN: Blinded crossover trial. ANIMALS: 22 castrated Beagles with experimentally induced chronic renal failure. PROCEDURE: Dogs were divided into 2 groups of 11 dogs each. During each of two 6-week treatment periods, dogs in 1 group received stanozolol, and those in the other group received a control agent. Nitrogen balance, body composition, and food consumption were determined. RESULTS: During administration of stanozolol, the amount of food consumed per dog, lean body mass, and nitrogen balance increased. Stanozolol did not have a significant effect on body fat, bone mineral content, or food consumption per kilogram of body weight. CLINICAL IMPLICATIONS: For dogs with mild-to-moderate, nonuremic, experimentally induced, chronic renal failure, stanozolol had positive effects on nitrogen balance and lean body mass.
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