Enkephalin-dopamine interactions in behavioral arousal.

R J Katz; B J Carroll

doi:10.1016/0364-7722(79)90052-3

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Enkephalin-dopamine interactions in behavioral arousal.

R J Katz·B J Carroll

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Abstract

1. Central injection of a long lasting enkephalin analog (D-Ala2-leu-enkephalin-amide) produced a syndrome of stereotyped motor activity. 2. This activation syndrome was significantly reduced by two dopamine (DA) blockers (pimozide, fluspririlene) and by an agonist of inhibition-mediating DA receptors [(3,4-dihydroxyphenylamino)-2-imidazoline]. 3. Intact DA functioning is necessary for the occurrence of this enkephalin-mediated behavioral syndrome.

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Animals Behavior, Animal Catecholamines Dopamine Agents Dopamine Antagonists Enkephalins Fluspirilene Imidazolines Male Mice Pimozide Receptors, Dopamine Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

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R J Katz, B J Carroll. 1979. Enkephalin-dopamine interactions in behavioral arousal.. https://doi.org/10.1016/0364-7722(79)90052-3

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