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PubMed · 4566969

[Progress in operative therapy: transplantation].

R Zenker
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Antilymphocyte SerumHeart TransplantationHistocompatibilityHistocompatibility AntigensHistocompatibility TestingHumansImmunosuppression TherapyKidney TransplantationLeukocytesLiver TransplantationLung TransplantationMethodsPancreas TransplantationTime FactorsTissue PreservationTransplantationTransplantation, HomologousJournal Article

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R Zenker. 1972. [Progress in operative therapy: transplantation].. https://doi.org/10.1007/bf01282625

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Allogeneic stem cell transplantation in a patient with dyskeratosis congenita after conditioning with low-dose cyclophosphamide and anti-thymocyte globulin.

Bone marrow failure is the major cause of early mortality in patients with dyskeratosis congenita (DC); early trials with conventional conditioning regimens were associated with remarkable chronic morbidity and mortality, and the optimal conditioning regimen for these patients remains undetermined. We report a case of a child afflicted with DC who underwent related full HLA-matched stem cell transplant (SCT) using a regimen of low dose cyclophosphamide and antithymocyte globulin (ATG). The regimen was well tolerated and associated with no significant short-term toxicity.

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