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PubMed · 458612

Conductivity and hardness changes in aged compacts.

R P Bhatia·N G Lordi
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Abstract

Batches of sodium, potassium, and ammonium chloride tablets containing no excipients and spray-dried lactose tablets containing 0.5% magnesium stearate were stored at 20 and 76% relative humidity. Electrical resistance and hardness measurements were made within 1 hr after compression and at intervals during a 45-day period. Hardness values of sodium, potassium, and ammonium chloride tablets stored at 20% relative humidity increased from 70 to 200% at 45 days, while conductances decreased 10-fold. Tablets stored at 76% relative humidity showed no increases or slight decreases in hardness with slight increases in conductance. Lactose tablets decreased slightly in hardness with corresponding increases in conductance.

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Ammonium ChlorideDrug CompoundingDrug StorageElectric ConductivityHardnessHumidityLactosePotassium ChlorideSodium ChlorideTabletsTime FactorsJournal Article

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BibTeXRIS

R P Bhatia, N G Lordi. 1979. Conductivity and hardness changes in aged compacts.. https://doi.org/10.1002/jps.2600680730

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