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Stability-indicating sulfa drug analysis using high-performance liquid chromatography.

H Umagat·P F McGarry·R J Tscherne
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Abstract

Sensitive and efficient methods for sulfonamide determination as single entities and in combination with other drug substances in pharmaceutical dosage formulations were developed using high-performance liquid chromatography. These stability-indicating procedures involved a nitrile bonded phase column and nonaqueous mobile phases having diverse polarities. Sample potency was determined using peak height measurements. The methods may be used to determine trace sulfonamide quantities because detection limits are in the nanogram range.

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Chemical PhenomenaChemistryChromatography, High Pressure LiquidDrug StabilityMethodsSulfonamidesJournal Article

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H Umagat, P F McGarry, R J Tscherne. 1979. Stability-indicating sulfa drug analysis using high-performance liquid chromatography.. https://doi.org/10.1002/jps.2600680741

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