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A structural modification study of procarbazine.

L T Weinstock·C C Cheng
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Abstract

Eight analogues of the antineoplastic compound procarbazine were prepared by varying one portion of the molecule, keeping either the methylhydrazinomethyl or the N-(1-methylethyl)benzamido portion of procarbazine intact. Preliminary screening results indicated that none of the analogues tested in leukemias L1210 and P388 were as active as the original compound.

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AnimalsAntineoplastic AgentsCarcinoma, Squamous CellHumansIn Vitro TechniquesLeukemia L1210Leukemia, ExperimentalMiceNeoplasms, ExperimentalProcarbazineJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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L T Weinstock, C C Cheng. 1979. A structural modification study of procarbazine.. https://doi.org/10.1021/jm00191a029

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