Translational control induced by bacteriophage T7.

P Herrlich; H J Rahmsdorf; S H Pai; M Schweigher

doi:10.1073/pnas.71.4.1088

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Translational control induced by bacteriophage T7.

P Herrlich·H J Rahmsdorf·S H Pai·M Schweigher

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Abstract

Phage T7 discontinues host gene expression by translational and transcriptional control mechanisms. Translational control is exerted by the T7 translational-repressor. This protein inhibits the synthesis of beta-galactosidase (EC 3.2.1.23) in vivo and in vitro and the synthesis of the T3 enzyme S-adenosylmethioninehydrolase (EC 3.3.1.-). The translational-repressor does not interfere with T7-specific enzyme synthesis. The T7 translational-repressor purifies with the initiation factors. The repressor interacts with the initiation of translation of host enzymes. The translational-repressor gene is close to the promotor for RNA polymerase of Escherichia coli.

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Chromosome Mapping Coliphages DNA Viruses DNA-Directed RNA Polymerases Enzyme Repression Escherichia coli Galactosidases Genes Genes, Regulator Hydrolases Peptide Chain Initiation, Translational Protein Biosynthesis S-Adenosylmethionine Transcription, Genetic Viral Proteins Journal Article

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P Herrlich, H J Rahmsdorf, S H Pai, M Schweigher. 1974. Translational control induced by bacteriophage T7.. https://doi.org/10.1073/pnas.71.4.1088

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