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PubMed · 4603159

Selection for high mutation rates in chemostats.

E C Cox·T C Gibson
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Abstract

Competition experiments in chemostats show that mutator populations of Escherichia coli are more fit than wild type. The increased fitness can be explained by the appearance of new mutants better adapted to the chemostat environment. Fitness values vary between chemostats and are strongly correlated (P < 0.001) with fluctuations in population density.

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Bacteriological TechniquesCarbon RadioisotopesCulture MediaEscherichia coliGenesGenetics, MicrobialGenotypeMutationProbabilitySelection, GeneticJournal Article

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E C Cox, T C Gibson. 1974. Selection for high mutation rates in chemostats.. https://doi.org/10.1093/genetics%2F77.2.169

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