PubMed · 4605520
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
R von Baehr, H Schwenke. 1974-04-15. [Autoimmunity and autoaggression].. https://pubmed.ncbi.nlm.nih.gov/4605520/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Yeast (Saccharomyces cerevisae) beta-1,3 glucans were used as adjuvant in a Vibrio damsela vaccine for turbot (Scophthalmus maximus L.). Turbot were injected with the adjuvant prior, at the same time and after the vaccine. Several immune parameters (index and rate of phagocytosis, passive haemolytic plaque numbers, and agglutinating antibody titers) were determined at different times postinoculation. The highest activity of all the immune parameters was obtained when glucans were injected after the bacterin. It is concluded that the sequence of glucan administration is critical when used as a vaccine adjuvant.
Explore the source record for details and available documents.
alpha-Lipoic acid (LA) is taken up by cells and reduced to its potent dithiol form, dihydrolipoate(DHLA), much of which is rapidly effluxed out from cells. To improve retention in cells, the LA molecule was modified to confer a positive charge at physiological pH. N,N-dimethyl,N'-2-amidoethyl-lipoate was synthesized. The protonated form of the new molecule is referred to as LA-Plus. The uptake of LA-Plus by human Wurzburg T cells was higher compared to that of LA. Several-fold higher amounts of DHLA-Plus, the corresponding reduced form of LA-Plus, were detected in LA-Plus treated cells compared to the amount of DHLA found in cells treated with LA. At 100 microM, LA did not but LA-Plus inhibited H2O2 induced NF-kappaB activation and NF-kappaB directed IL-2 receptor expression. Both LA and LA-Plus synergised with selenium in inhibiting H2O2 induced NF-kappaB activation. At 150 microM LA-Plus, but not LA, inhibited TNFalpha induced NF-kappaB activation. At 5 microM LA-Plus, but not LA, protected against both spontaneous and etoposide induced apoptosis in rat thymocytes. LA-Plus is thus an improved form of LA with increased therapeutic potential.