PubMed · 4606400
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M Seligmann, E Mihaesco. 1974. Current knowledge on alpha chain disease.. https://doi.org/10.1007/978-1-4613-4550-3_43
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The clock gene period determines biological rhythmicity in Drosophila melanogaster and encodes a protein characterized by an alternating series of threonine-glycine pairs. The minisatellite region encoding the threonine-glycine repeat is polymorphic in length in natural Drosophila melanogaster populations. In this paper we report the geographical analysis of this polymorphism within Europe and North Africa. A robust clinal pattern is observed along a north-south axis. We suggest the possibility that the length polymorphism could be maintained by thermal selection because the threonine-glycine region has been shown to provide thermostability to the circadian phenotype.
The epidemiology of visceral and cutaneous leishmaniasis is described in the Mediterranean countries where a recrudescence and a geographical spread of these zoonoses are noted. Recent findings concerning isoenzyme identification of the causative agents are given and the problems encountered in the development of vaccines to protect humans and dogs are discussed.