PubMed · 4639960
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R B Cross, J Trace. 1972. Inexpensive constant pressure pulsatile perfusion pump.. https://pubmed.ncbi.nlm.nih.gov/4639960/
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The objective of this study was to evaluate the reliability of pressure measurements by the main catheters used to determine urethral profiles by the perfusion method. This evaluation, performed on a test bench, compared the reference pressure in a tank filled with water to that measured by the catheter tested. The reliability of the measurement varied from one catheter to another. This disparity was due to differences of load losses, leading to an overestimation of the measurement (by 2 to 17 centimetres of water), which must be corrected by adjustment of the zero pressure with a perfused catheter. Major differences in the rapidity of response (from zero to five seconds) were also observed, which appear to be related to elastic properties of the catheter. This study does not pretend to globally verify the reliability of the perfusion method, but only the reliability of pressure measurements.
Repeated sampling of a drug solution that is recirculated through a perfused body increases the rate of drug disappearance from the perfusate. When the volume of the drug solution (VT) is maintained constant by addition of drug-free perfusate after sampling, the measured drug concentration (Ci) can be corrected for drug removed in previous samples by using the equation C'i = CiVTC'i-1/(VT - VS)Ci-1, where C'i is the corrected drug concentration in the ith sample, VS is the volume of the sample, and C'1 = C1. An error in an particular Ci is not transmitted to a subsequent C'i value. The method can be used when the time interval between samples and when VS vary from sample to sample, but return of the drug from the perfused body to the perfusate after sampling may cause C'i to be overestimated.
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