PubMed · 4665666
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P H Hofschneider. 1972. [Viruses as "programmed instruction"].. https://pubmed.ncbi.nlm.nih.gov/4665666/
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Vibrio cholerae induced auxotrophic variants nonfermenting several carbohydrates simultaneously have been obtained for the first time. Eltor vibrio clones have been selected, referred to Heuberg's groups V and VI by their enzymic activities. The findings of the present study evidence that, when isolating Eltor vibrio strains negative towards differential carbohydrates, in case of a positive agglutination test, the incubation period should be prolonged to 3 days. The principal differential diagnostic test for this species, when cholera is bacteriologically diagnosed, should be a positive volumic agglutination test with species- and variant-specific sera, irrespective of Heuberg's group.
It is generally assumed that genetic research of mycobacteria is delayed as compared with other, more commonly used, bacterial models, particularly in the field of genetic transfers. In the field of mutagenesis the problems have been studied to such an extent that replication maps of the chromosome of M. phlei and M. tuberculosis H37 Rv have already been constructed and a new model of the cell cycle of bacteria exhibiting a slow growth rate has been worked out. When the problems of mycobacterial genetics are looked upon in the light of gene manipulations it may be concluded that mycobacteria belong to a few models whose genes are used for cloning and that problems of practical significance will be studied by means of the most modern approaches.