Pyrethroid insecticides: esterase cleavage in relation to selective toxicity.

C O Abernathy; J E Casida

doi:10.1126/science.179.4079.1235

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Pyrethroid insecticides: esterase cleavage in relation to selective toxicity.

C O Abernathy·J E Casida

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Abstract

The ester group of primary alcohol chrysanthemates is cleaved by mouse hepatic microsomal esterases, more rapidly for the (+)-trans than for the (+)-cis isomers. Substrate-specificity and inhibition studies in vivo establish that these pyrethroid-hydrolyzing esterases probably contribute to the low mammalian toxicity of bioresmethrin and other (+)-trans chrysanthemate insecticide chemicals derived from primary alcohols.

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Animals Chrysanthemum cinerariifolium Drug Synergism Esterases Hydrolysis Lethal Dose 50 Mice Microsomes, Liver Phosphoric Acids Stereoisomerism Journal Article

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C O Abernathy, J E Casida. 1973-03-23. Pyrethroid insecticides: esterase cleavage in relation to selective toxicity.. https://doi.org/10.1126/science.179.4079.1235

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