PubMed · 4714716
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1973. Diagnostic Doppler instruments.. https://doi.org/10.1016/0041-624x(73)90589-1
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A new transducer has been developed, based on an inductive principle, for recording fetal movements and sounds. The compliance of this transducer, the INductive PHOno-sensor (INPHO), can be matched to that of the maternal abdomen to provide an optimal transfer of displacement between maternal abdomen and transducer. In this manner, it is possible to detect fetal breathing movements by digital filtering of the INPHO signal in a frequency band between 0.5 and 2.0 Hz. Singular breathing movements can be detected and this was verified by real time ultrasound imaging. The INPHO transducer shows a flat (+/- 1.5 dB) frequency response between 0.2 and 200 Hz. The signal-to-noise ratio of the transducer system is better than 95 dB, and enables very weak movements and sounds to be detected. Spectral analysis of the processed signal shows that modulation of fetal breathing by maternal breathing takes place. The measuring setup allows for the quantitative assessment of fetal respiratory sinus arrhythmia.
The polymerase chain reaction provides a rapid method for the molecular cloning of DNA probes suitable for the detection of specific messenger RNA. We have used this approach to prepare probes specific for human cardiac myosin messenger RNA and demonstrate here the use of such probes in the analysis of human cardiac development by hybridization in situ to sections of fetal tissue. This combination of techniques is suitable for the detection of any messenger RNA for which sequence data are available, and offers a powerful new approach to the analysis of cardiac development.
During gestation the abdominally recorded fetal ECG (FECG) changes as a result of changes in the conductive medium. In particular, a minimum occurs in the FECG amplitude around 30 weeks of gestation. Based on the results of an extensive FECG study, the effect of these changes on the fetal MCG are simulated. It is shown that the FMCG amplitude is not greatly affected by the changes in the conductive medium. The FMCG waveform, however, is.