PubMed · 482950
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1979. Nuclear imaging agents: ventricular visualization--brain imaging.. https://pubmed.ncbi.nlm.nih.gov/482950/
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A 47-year-old right-handed woman suffered an accidental dural perforation in the course of intranasal drainage of a right-sided sphenoid mucocele. Radiological examination revealed a small hematoma involving the anterior commissure, the right foramen of Monro, and the right fornix, resulting in severe anterograde amnesia for visual stimuli. Visual retention disturbances were manifested by a loss of the ability to conjure up new visual images, loss of topographical memory, and the cessation of dreaming. Dissociation was striking between severe deficits on tests exploring anterograde visual memory, revisualization, visuospatial organization, construction abilities, and normal or mildly impaired performance on tests implying verbal material and verbal memory. In agreement with experimental findings, it is postulated that combined damage to the anterior commissure and fornix on the right side could cause severe deficits in visual retention in humans.
A newly developed liquid chromatographic system with a multiple electrode detector was used for quantification of neurochemical substances in ventricular fluid of patients with Parkinson's disease. During the analysis, an unknown peak was observed at almost the same high-performance liquid chromatography retention time as 5-hydroxytryptophan. Through the use of ion suppression techniques, voltammographic analysis and fast atom bombardment mass spectrometry, the compound was identified as O-methyldopa, the major metabolite of L-dopa.