PubMed Health⌕ Search

PubMed · 4830137

Error rates in cervical cytological screening tests.

Abstract

In an attempt to clear up the confusion evident in the literature concerning some aspects of cervical cytological screening tests, the principle is stated upon which the data acquired in a series of tests should be tabulated. The table is used to define several rates or probabilities, most of which express the rates at which errors occur. Certain rates are distinguished as of basic importance, others playing only a secondary role. The inter-relations of the rates are displayed as equations and reference is made to a set of conversion tables constructed from the equations. As an illustration, the data from a particular published paper is treated in detail, showing how the various rates can be calculated or estimated, and, in passing, also demonstrating their high degree of uncertainty.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

D May. 1974. Error rates in cervical cytological screening tests.. https://doi.org/10.1038/bjc.1974.46

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Non-radical diagnostic biopsies do not negatively influence melanoma patient survival.

BACKGROUND: In fair-skinned Caucasian populations both the incidence and mortality rates of cutaneous melanoma have been increasing over the past decades. With adjuvant therapies still being under investigation, early detection is the only way to improve melanoma patient survival. The influence of incisional biopsies on melanoma patient survival has been discussed for many years. This study investigates both the influence of diagnostic biopsy type and the presence of residual tumor cells in the re-excision specimen on disease free and overall survival. METHODS: After (partial) removal of a pigmented skin lesion 471 patients were diagnosed with stage I/II melanoma and underwent re-excision and a sentinel node biopsy. All patients were followed prospectively, mean follow up >5 years. Patients were divided according to their diagnostic biopsy type (wide excision biopsy, narrow excision biopsy, excision biopsy with positive margins and incisional biopsy) and the presence of residual tumor cells in their re-excision specimen. Survival analysis was done using Cox's proportional hazard model adjusted for eight important confounders of melanoma patient survival. RESULTS: The diagnostic biopsy was wide in 279 patients, narrow in 109 patients, 52 patients underwent an excision biopsy with positive margins and 31 patients an incisional biopsy. In 41 patients residual tumor cells were present in the re-excision specimen. Both the diagnostic biopsy type and the presence of tumor cells in the re-excision specimen did not influence disease free and overall survival of melanoma patients. CONCLUSIONS: Non-radical diagnostic biopsies do not negatively influence melanoma patient survival.

Biopsy↗