PubMed · 4868009
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1968-03-30. Cadaveric kidneys.. https://pubmed.ncbi.nlm.nih.gov/4868009/
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We consider a model for mortality rates that includes both the long and short term effects of switching from an initial to a second state, for example, when patients receive an initial treatment and then switch to a second treatment. We include transient effects associated with the switch in the model through the use of time-dependent covariates. One can choose the form of the time-dependent covariate to correspond with a variety of possible transition patterns. We use an exponential decay model to compare the survival experience of transplant versus dialysis treatment of end stage renal disease (ESRD) patients from the Michigan Kidney Registry (MKR). This model involves a hazard function that has an initial effect in mortality at the time of transplant, expected to be higher, followed by a smooth exponential decay to a long term effect, expected to be lower than the risk for those remaining on dialysis. Cox and Oakes used this model to analyse the Stanford Heart Transplant data. The model implicitly suggests there is a time at which the hazard curves (and survival curves) for the treatment groups cross. Those crossing times are useful in advising patients who have the option of receiving a transplant. We describe methods for obtaining estimates of the crossing times and their associated variances, and then apply them in analysing the MKR data.
The management of severe compound tibial fractures is aimed at obtaining osseous consolidation, proper cutaneous and muscular cover, absence of infection and restoration of limb function. A knowledge of the cutaneous and muscular vascularisation allows the surgeons to use many flaps in a rational and predictable manner. One of the most commonly used flaps is the soleus muscular flap. This may be used as a proximally or distally based muscular flap and the use of a hemisoleus flap has also been described. A morphometric analysis of the relation between tibial length and soleus vascular pattern provides a simple and reliable method for planning this flap preoperatively. The study was performed on fresh and preserved cadavers.
Based on a prospective study of 30 right or left femurs removed in a continuous series in the anatomy department, a study was made of the dimensions of the endosteal canal of the upper end of the femur. The femora were analysed by means of 12 CT scans below the lesser trochanter. The sections were numbered and the dimensional parameters calculated by computer, using an original plan. The results were subjected to descriptive and correlative analysis. From these dimensional findings it appeared that the anatomy of the upper end of the femur is not random; morphotypic models exist and the laws of a normal model are regulated by a mathematical equation.