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Heart transplantation, problems and progress.

P S Russell
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Antilymphocyte SerumHeart TransplantationHistocompatibilityHistocompatibility TestingHumansImmunosuppressive AgentsTissue DonorsTransplantation ImmunologyTransplantation, HomologousJournal Article

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P S Russell. 1969-05-15. Heart transplantation, problems and progress.. https://doi.org/10.1056/nejm196905152802010

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Allogeneic stem cell transplantation in a patient with dyskeratosis congenita after conditioning with low-dose cyclophosphamide and anti-thymocyte globulin.

Bone marrow failure is the major cause of early mortality in patients with dyskeratosis congenita (DC); early trials with conventional conditioning regimens were associated with remarkable chronic morbidity and mortality, and the optimal conditioning regimen for these patients remains undetermined. We report a case of a child afflicted with DC who underwent related full HLA-matched stem cell transplant (SCT) using a regimen of low dose cyclophosphamide and antithymocyte globulin (ATG). The regimen was well tolerated and associated with no significant short-term toxicity.

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