PubMed · 490939
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
M Kitamura, K Murakawa. 1979-06-29. [Amylase].. https://pubmed.ncbi.nlm.nih.gov/490939/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
The effects of the phosphatase inhibitors calyculin A and okadaic acid on amylase release from streptolysin-O permeabilized rat pancreatic acini were investigated. Both agents induced similar biphasic effects with moderate potentiation of calcium-stimulated amylase release at medium and strong inhibition at higher concentrations. Calyculin A was thirty times more potent than okadaic acid and at 100 nM totally inhibited calcium-induced amylase release while 3 microM okadaic acid reduced amylase release by 78%. 100nM calyculin A also completely inhibited GTP gamma S-potentiated amylase release and partially inhibited phorbol ester potentiated secretion. The data indicate that inhibition of a serine/threonine phosphatase, probably a type 1 phosphatase, leads to inhibition of calcium-induced amylase release in permeabilized pancreatic acini.
Explore the source record for details and available documents.
Explore the source record for details and available documents.