[Highly permeable intercellular junctions in normal and transformed fibroblast cultures].

L Iu Boĭtsova; Iu M Vasil'ev; T V Potapova

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PubMed · 49116

[Highly permeable intercellular junctions in normal and transformed fibroblast cultures].

L Iu Boĭtsova·Iu M Vasil'ev·T V Potapova

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Abstract

Intercellular junctions permeable to ions and fluorescein Na were studied with the aid of intracellular microelectrodes in the cultures of normal and transformed mouse-embryo and hamster-embryo fibroblast-like cells. Normal cells were effectively coupled by the highly permeable junctions. In cultures of 7 types of transformed cells, 3 types of coupling were detected: effective, decreased, and fully reduced couplings. The degree of uncoupling was not correlated with morphological patterns of malignization and tumorogeneity of transformed cultures. The decrease of permeability of intercellular junctions to ions and small molecules is concluded not to be necessary for malignization.

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Animals Cell Line Cell Membrane Permeability Cell Transformation, Neoplastic Cells, Cultured Cricetinae Culture Media Cytological Techniques Fibroblasts Intercellular Junctions Membrane Potentials Mice Microelectrodes Microscopy, Fluorescence Sarcoma, Experimental Staining and Labeling Time Factors English Abstract Journal Article

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L Iu Boĭtsova, Iu M Vasil'ev, T V Potapova. 1975. [Highly permeable intercellular junctions in normal and transformed fibroblast cultures].. https://pubmed.ncbi.nlm.nih.gov/49116/

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