Carcinogen and microsomal membrane interactions: changes in membrane density and ability to bind nucleic acids.

H Kubinski; C B Kasper

doi:10.1126/science.171.3967.201

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Carcinogen and microsomal membrane interactions: changes in membrane density and ability to bind nucleic acids.

H Kubinski·C B Kasper

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Abstract

DNA and synthetic copolymer polyribocytidylic-polyriboguanylic acid bind to microsomal membrane. The nucleic acid-membrane complex may be detected by centrifugation in cesium chloride density gradients. The density of the nucleic acid-membrane complex and, in certain cases, the amount of nucleic acid associated with the membrane was changed in the presence of various carcinogenic chemicals.

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Animals Binding Sites Carcinogens Carcinoma, Ehrlich Tumor Centrifugation, Density Gradient Cytosine Nucleotides DNA, Bacterial Escherichia coli Guanine Nucleotides Membranes Microsomes, Liver Polynucleotides RNA, Bacterial RNA, Neoplasm Rats Specific Gravity Journal Article

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H Kubinski, C B Kasper. 1971-01-15. Carcinogen and microsomal membrane interactions: changes in membrane density and ability to bind nucleic acids.. https://doi.org/10.1126/science.171.3967.201

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