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PubMed · 4989828

Epidermal growth factor: high and low molecular weight forms.

J M Taylor·S Cohen·W M Mitchell
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Abstract

In crude homogenates of the submaxillary gland of the male mouse, epidermal growth factor (EGF) activity was found almost entirely in a high molecular weight complex (about 74,000 daltons). This high molecular weight form may be reversibly dissociated into EGF and an EGF-binding protein. EGF was found to have a molecular weight of approximately 6400. The EGF-binding protein has a molecular weight of 29,000, and shows arginyl-esterase activity.

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Amino AcidsAnimalsArginineChromatography, GelChromatography, Ion ExchangeElectrophoresis, DiscEsterasesGrowth SubstancesImmune SeraImmunodiffusionIsoelectric FocusingMaleMiceMolecular WeightPeptidesProtein BindingRabbitsSubmandibular GlandUltracentrifugationJournal Article

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J M Taylor, S Cohen, W M Mitchell. 1970. Epidermal growth factor: high and low molecular weight forms.. https://doi.org/10.1073/pnas.67.1.164

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